discontinue donepezil and start memantine alongside a donepezil placebo continue on donepezil and start memantine Patients, caregivers, clinicians, researchers and statisticians were unaware of the treatments that were assigned. Evidence-based recommendations on donepezil (Aricept), galantamine (Reminyl), rivastigmine (Exelon) and memantine (Ebixa) for treating Alzheimer's disease in adults. Evidence-based information on side effects f donepezil from hundreds of trustworthy sources for health and social care. Donepezil, galantamine and rivastigmine can be prescribed for people with early- to mid-stage Alzheimer's disease. The latest guidelines recommend that these medicines should be continued in the later, severe, stages of the disease. Cholinesterase inhibitors (donepezil, rivastigmine and galantamine) In the brain of a person with Alzheimer’s disease, there are lower levels of a chemical called acetylcholine. Acetylcholine helps to send messages between certain nerve cells. The operation that you have selected will move away from the current results page, your download options will not persist. Please click Confirm if you are happy to lose these search results. This follow up study examined whether the drugs donepezil or memantine affected the chance that people with Alzheimer’s disease could continue to live in the community, rather than move permanently to a nursing home. Working in partnership Integrated Medication Guidelines for Use of Donepezil, Galantamine, Rivastigmine and Memantine in Alzheimer’s Disease Objectives: Safe prescribing in dementia Innovative thinking in dementia prescribing and care Prioritising patient and carer convenience Improving efficiencies and timely access to services Supporting. discontinue donepezil and start memantine alongside a donepezil placebo continue on donepezil and start memantine Patients, caregivers, clinicians, researchers and statisticians were unaware of the treatments that were assigned. Dementia causes the (usually gradual) loss of mental abilities such as thinking, remembering and reasoning.Brought to you by NHS Choices.